Anti-hypercholesterolemia and Anti-hyperlipidemic Effect of Lactobacillus plantarum and Lactobacillus acidophilus in Diabetic Rats

Abstract

This study was aimed to determine the cholesterol lowering and maintaining lipid profile effects of Lactobacillus strains in alloxan induced diabetic rats. Diabetic rats were treated with Lactobacillus plantarum and Lactobacillus acidophilus (108 CFU/ml) orally for 2 h or 21 days followed by measuring body weight and serological biomarkers such as triglyceride, total cholesterol, HDL, LDL, VLDL, TC/HDLC ratio and LDLC/HDLC ratio. After the administration of Lactobacillus strains for 21 days TG, TC, VLDL cholesterol and LDL cholesterol levels were significantly (P < 0.001) increased, whereas HDL cholesterol was decreased in diabetic rats compared to normal rats. Both the Lactobacillus strains exhibited significant reduction (P< 0.001) in all tested lipid and body weight parameters and restored them to nearly-normal values. The findings confirm anti-hypercholesterolemia and anti-hyperlipidemic efficacy of Lactobacillus spp.