Natural bioactive compounds: An alternate strategy for Glioblastoma multiforme diagnosis and therapy

Abstract

Over 10,000 cases of Glioblastoma multiforme are reported in the United States annually, making it one of the most dangerous malignant tumours. Numerous clinical evaluations and investigations demonstrate the interaction between pathogenesis and the increase of cell-reactive radicals in certain chronic diseases, such as cancer. Exogenous sources (xenobiotic interaction) and endogenous sources (physiological activities) are the two categories of sources of reactive nitrogen and reactive oxygen. When antioxidant regulatory mechanisms are circumvented, cellular oxidation/reduction transforms into oxidative stress, increasing the danger of cellular lipid, protein, and nucleic acid damage. Bioactive chemicals and their derivatives are used to treat Glioblastoma multiforme. As nanomedicine formulations for enhanced cancer theranostics relative to conventional approaches, these can be utilised independently, in conjunction with anticancer treatments, or all three. The paramount importance of phytochemicals in this context is the main topic of this review. In conclusion, the anti-inflammatory, anti-cancer, and antioxidant properties of bioactive molecules included in fruits, vegetables, and seeds may improve post-chemotherapy or post-treatment symptoms for cancer survivors. However, this could be a viable therapeutic approach for this tumour type if they are included in the drug delivery system based on nanocarriers for the treatment of GBMs. This target-specificity reduces off-target organ aggregation and improves medication internalisation into cells. Along with higher bioavailability and lower adverse effects, targeting effectiveness is also increased.