Phytochemical Analysis and Anti-Stress Adaptogenic Potential of Hydro-Alcoholic Extract of Ocimum sanctum

Abstract

The aim of the present study was to investigate phytochemical analysis of major bioactive compounds present in hydro-alcoholic extract of Ocimum sanctum. Soxhlet apparatus was used for the extraction. Further, this research examined the adaptogenic potential of hydro-alcoholic extract of Ocimum sanctum in experimental Swiss albino mice. Three doses, 100, 150, and 200 mg/kg of the hydro-alcoholic extract prepared as a suspension in 2 ml of 2 % gum acacia were used. Swim endurance and anoxic stress tolerance tests were performed in Swiss albino rats. Potential effects of Ocimum sanctum were observed for reducing the stress level in a dose dependent manner. These findings indicated that Ocimum sanctum has significant adaptogenic activity with a therapeutic potential in the treatment of autoimmune disorders.