Vol. 2 No. 2 (2026): Drug Discovery and Development

This issue of Drug Discovery and Development highlights critical advances across drug design, targeted delivery, and pharmaceutical ecotoxicology. In molecular chemistry, research showcases the design, synthesis, and biological evaluation of pyrazole and imidazole derivatives as promising core scaffolds for novel drug discovery. In advanced therapeutics, featured studies explore glycerosomes as sophisticated vesicular delivery systems, detailing a novel griseofulvin-loaded glycerosomal nanogel for targeted topical management of onychomycosis, as well as the in vivo antifungal evaluation of Parmelia perlata extracts. Complementing these therapeutic innovations, the issue addresses environmental safety by examining the ecotoxicological risks of clinical SSRIs (specifically sertraline and fluoxetine) on freshwater fish species. Together, these contributions bridge molecular design, delivery engineering, and environmental impact assessment.