Formulation and development of griseofulvin-loaded glycerosomal nanogel for the management of onychomycosis

Abstract

The study focused on the development and evaluation of Griseofulvin-loaded glycerosomal nanogels for the treatment of Onychomycosis using the lipid thin-film hydration technique. This method was employed to prepare several formulation batches (F1-F6) with the aim of optimizing the drug delivery system by varying the concentration of glycerol. Among these formulations, some batches were excluded based on preliminary evaluation parameters, including particle size and entrapment efficiency. The nanogels were formulated using lecithin as a phospholipid to enhance drug encapsulation efficiency. Their physicochemical characteristics, such as particle size and morphology, were evaluated using transmission electron microscopy (TEM). The optimized formulations were further analyzed for particle size distribution and in-vitro drug release in phosphate buffer solution (pH 7.4). In addition, stability studies were carried out under different storage conditions to evaluate the effect of temperature on formulation integrity and stability. The primary objective of this research was to improve drug penetration through the nail bed and reduce the frequency of drug administration, thereby enhancing patient compliance. The findings suggest that the lecithin-based lipid thin-film hydration technique is a promising strategy for the effective delivery of Griseofulvin in the management of Onychomycosis.