Microbial Extracellular L-asparaginase: An Enzyme of Therapeutic Interest

Authors

  • Biswaprakash Pradhan Pharmaceutical Biotechnology Division, University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar, Odisha -751 004, India Author
  • Sashi K. Dash Department of Seed Technology, Orissa University of Agriculture and Technology, Bhubaneswar, Odisha -751 003, India Author
  • Chandi C. Rath Deputy Director (Technical), Biotechnology, Govt. of Odisha, Bhubaneswar-751001, India Author
  • Sweety Patel State Drugs Testing and Research Laboratory, Directorate of Drugs Control, Bhubaneswar, Odisha, India Author
  • Sabuj Sahoo Pharmaceutical Biotechnology Division, University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar, Odisha -751 004, India Author

DOI:

https://doi.org/10.5530/jam.1.2.2

Keywords:

L-asparaginase, Acute Lymphoblastic Leukemia (ALL), Enzymatic Assay, Therapeutic Application

Abstract

This review article encompases detailed information pertaining to microbial extracellular L-asparaginase, the introductory remarks on current status and future perspective of enzymes in general and overview of L-asparaginage in specific, underlying mechanism of action, therapeutic applications, microbial sources, effect of fermentation process parameters on its production, methods for purification, molecular weight and properties, biochemical aspects, assay methods side effects, therapeutic importance and scope of research. Effort has been made for inclusion of updated information and impact of newer parameters including fermentation processes, different methods for purification, properties and biochemical aspects of microbial extracellular Lasparaginase. L-asparaginase is still one of the most widely studied therapeutic enzymes by researchers and scientists worldwide.

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Published

2024-01-31

How to Cite

Microbial Extracellular L-asparaginase: An Enzyme of Therapeutic Interest. (2024). Journal of Advanced Microbiology, 1(2), 75-88. https://doi.org/10.5530/jam.1.2.2

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