Microbial Extracellular L-asparaginase: An Enzyme of Therapeutic Interest

Abstract

This review article encompases detailed information pertaining to microbial extracellular L-asparaginase, the introductory remarks on current status and future perspective of enzymes in general and overview of L-asparaginage in specific, underlying mechanism of action, therapeutic applications, microbial sources, effect of fermentation process parameters on its production, methods for purification, molecular weight and properties, biochemical aspects, assay methods side effects, therapeutic importance and scope of research. Effort has been made for inclusion of updated information and impact of newer parameters including fermentation processes, different methods for purification, properties and biochemical aspects of microbial extracellular Lasparaginase. L-asparaginase is still one of the most widely studied therapeutic enzymes by researchers and scientists worldwide.