Biological Activities of Various Triazolone Derivatives

Abstract

Triazolones are known as a class of 5-membered heterocyclic compounds comprising three nitrogen atoms on 1, 2 and 3-position of the ring along with one carbonyl group (C=O), either at 3-position or 5-position resulting in triazol-3-one and triazol-5- one respectively. Therapeutic potential of triazolones has attracted various researchers and has been explored extensively. Triazolones and their derivatives had shown a broad spectrum of biological activities such as antimicrobial, anticonvulsant, antioxidant, anticancer, analgesic, anti-nociceptive, and anti-inflammatory properties. In the present study, we have made an effort to compile various structural variations on triazolone nucleus and their reported pharmacological activities.