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Abstract: The aim of the present study was to investigate phytochemical analysis of major bioactive
compounds present in hydro-alcoholic extract of Ocimum sanctum. Soxhlet apparatus was used for the extraction.
Further, this research examined the adaptogenic potential of hydro-alcoholic extract of Ocimum sanctum in
experimental Swiss albino mice. Three doses, 100, 150, and 200 mg/kg of the hydro-alcoholic extract prepared as
a suspension in 2 ml of 2 % gum acacia were used. Swim endurance and anoxic stress tolerance tests were
performed in Swiss albino rats. Potential effects of Ocimum sanctum were observed for reducing the stress level
in a dose dependent manner. These findings indicated that Ocimum sanctum has significant adaptogenic
activity with a therapeutic potential in the treatment of autoimmune disorders.