Food And Pharma International

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Abstract: The present study was undertaken to investigate the anti-inflammatory and analgesic activities
of ethanolic extract of Stevia rebaudiana leaf in experimental rats. Swiss albino rats were administered with oral
dose of ethanolic leaf extract of S. rebaudiana at the doses of 200, 300, 400 and 500 mg/kg body weight, and
studied for its anti-inflammatory and analgesic activities by using carrageenan-induced hind paw edema, acetic
acid-induced writhing, hot plate reaction and tail immersion test in albino rats. Inhibition in paw volume was
measured plethysmometrically at different time intervals after carrageenan (1% w/v) injection. As a result, the
ethanolic leaf extract of S. rebaudiana showed anti-inflammatory and analgesic effects in dose dependent
manner when compared with the control and standard drug, aspirin (100 mg/kg, p.o). The paw volumes, pyrexia
and writhes in experimental rats were reduced significantly (p < 0.05) as compared to that of control, and hot
plate test showed significant licking effect in rats. Phenylbutazone, aspirin, morphine and diclofenac sodium
were employed as reference drugs for analgesic and anti-inflammatory studies. In the present study, high
dosages of the ethanolic leaf extract of S. rebaudiana (300, 400 and 500 mg/kg body weight) demonstrated
significant anti-inflammatory and analgesic activities in the tested models. Findings of this investigation
suggested a potential benefit of ethanolic leaf extract of S. rebaudiana in treating conditions associated with
pain and inflammation.