Drug Discovery and Development

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Abstract: Triazolones are known as a class of 5-membered heterocyclic compounds comprising three
nitrogen atoms on 1, 2 and 3-position of the ring along with one carbonyl group (C=O), either at 3-position
or 5-position resulting in triazol-3-one and triazol-5- one respectively. Therapeutic potential of triazolones
has attracted various researchers and has been explored extensively. Triazolones and their derivatives had
shown a broad spectrum of biological activities such as antimicrobial, anticonvulsant, antioxidant, anticancer,
analgesic, anti-nociceptive, and anti-inflammatory properties. In the present study, we have made an effort to
compile various structural variations on triazolone nucleus and their reported pharmacological activities.

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